SRF Antibody Price
BACKGROUND: Human SRF (508 amino acids) is a member of the MADS box family of transcription factors. SRF regulates many genes involved
in cell cycle control, differentiation, apoptosis, and embryonic development through interactions with the conserved promoter serum response
element. The diverse functions of SRF are also mediated through the recruitment of many general and sequence-specific transcription factors,
highlighting the central role of protein interaction in transcriptional regulation by SRF. SRF itself can be activated by many agents including serum,
cytokines, growth factors, tumor promoters, LPS, and UV light. The gene is a primary target of the MAPK signal transduction pathway through the
ternary complex factors (TCFs). RhoA signaling also regulates the activity of SRF during muscle differentiation. The polyclonal antibody was
produced by immunizing rabbits with a synthetic peptide corresponding to a C-terminal region (400-450) of human SRF.
Biomedical Research Service
& Clinical Application
Staining of myoblast nuclei by the SRF
antibody in culture.