Myosin Heavy Chain (MYH) Antibody                                                                                                                                                               Price

BACKGROUND: Myosins consist of a large family of motor proteins that interact with the actin filament to generate contractile force. These large
structural proteins (~220 kDa) can be grouped into ~20 classes in eukaryotes on the basis of their sequences in the ATP-hydrolyzing domains.
Each myosin assembly contains a pair of myosin heavy chain (MYH) and two pairs of myosin light chain (MYL). At least 10 MYH isoforms have
been described in mammalian striated, smooth, and non-muscle cells. For instance, the MYH1, 2, 3, 4, 8, and 13 genes encode the skeletal muscle
isoforms whereas the MYH6 and MYH7 encode the cardiac muscle isoforms. MYH11 encodes the smooth muscle isoform. MYH9, 10, and 14
encode the non-muscle isoforms. The polyclonal antibody was produced by immunizing goats with rabbit muscle MYH proteins. The MYH antibody
strongly recognizes the skeletal and cardiac muscle isoforms with some affinity for the non-muscle isoforms. Reactivity against the smooth muscle
isoform has not been characterized.
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A hamster hamstring muscle
paraffin section was stained by the
myosin heavy chain antibody
(green color). The stained muscle
exhibits clear sarcomeric striation.
Nuclei were stained blue by DAPI.
Pink color depicts phospho-STAT3
staining.
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