GH (Growth hormone/Somatotropin) Price
BACKGROUND: Human growth hormone (GH), also known as somatotropin, is synthesized in the anterior pituitary as a 217-amino acid precursor,
which is further cleaved to generate the mature 191-amino acid (22 kDa) cytokine. Through binding to the GH receptor, it exhibits potent pleiotropic
biological effects in an IGF1-dependent and -independent manner. Prominent signal transduction events activated by GH include the JAK/STAT
and MAPK/ERK pathways, culminating in IGF1 production and growth promotion. Other significant effects of GH are activation of lipolysis,
stimulation of protein synthesis, and augmentation of immune function. Since this function of GH is generally anabolic, it has been explored clinically
to treat short stature in children. Bovine GH is used to increase milk production in dairy cows. Human and bovine GH amino acid sequences are
67% homologous, rendering the effects of GH species-specific. The human GH is over-produced and purified from E. coli.
Biomedical Research Service
& Clinical Application
Human GH activity is assessed by its ability to
promote HL1 myocyte proliferation. MTT Assay
was performed three days after the treatment.
Higher concentrations of GH were found to be
less effective in promoting HL-1 proliferation.