Granulocyte colony stimulating factor (G-CSF or CSF-3)                                                                                                                          Price

BACKGROUND: Human graunlocyte colony stimulating factor (G-CSF or CSF-3) is a potent multi-functional growth factor/cytokine produced by
endothelial cells, fibroblasts, and immune cells. It is capable of mobilizing bone marrow hematopoietic stem cells, promoting growth and
differentiation of neutrophils, and inducing neurogenesis. These actions involve interaction with its specific membrane receptor, causing
activation of multiple signaling complexes such as JAK/STAT3, ERK, and AKT. The gene is located on chromosome 17, and produces five splice
variants. The longest splice form encodes a 30-amino acid signal peptide and 177-amino acid mature peptide. Clinically, G-CSF (
Filgrastim or
) is used to facilitate recovery from neutropenia after chemotherapy. Neulasta is pegylated G-CSF possessing prolonged in vivo
stability. Unlike growth hormone, G-CSF is not species specific. Although the protein is glycosylated, glycosylation is apparently not essential for
its functions. The human G-CSF is over-produced and purified from E. coli.
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